The risks associated with laboratory rats can be chemical, physical, biological, electrical, ergonomic, or a combination of these. Associate Director of the Center for Comparative Medicine 434-924-2090 Jennifer Branum UVA Biosafety Officer Alternate Responsible Official (Select Agents) 434-982-4911 Marie Burdick IBC Member Principal Scientist Department of Medicine, Pulmonary and Critical Care 434-243-7363 Sam Driver IBC Member Community Member Methods: Gastric acid secretion was measured in ligated stomachs, while anti-parietal cell antibodies were assayed by immunofluorescence and en... Crohn's disease (CD) can develop in any region of the gastrointestinal tract, including the stomach. Sorry, you need to be a researcher to join ResearchGate. The Genome Analysis and Technology Core provides high throughput (Next Generation) sequencing services for both novices and experienced users alike, by providing timely assistance in all facets of experimentation from project design/execution to data analysis/reporting. It houses three electron microscopes, a 120kV Spirit, a 200kV F20, and a 300kV Titan Krios. Only verified researchers can join ResearchGate and send messages to other members. UVA Cancer Center ID: SEC-012 - Biosafety. Within weeks of identification of this first case, immune-deficient mice of various genotypes from the same facility were similarly affected, and cases from other facilities were found within two months. ID: SEC-006 - Regulated Medical Waste Management. Methods: 1 microfilm reel ; 35 mm. lizards, Survival Risk Assessment for Primary Blast Exposures to the Head, Spontaneous Autoimmune Gastritis, Hypochlorhydria and Bacterial Overgrowth in the Ileitis-Prone, SAMP1/Yit Mice, Association of Mycoplasma corogypsi and Polyarthritis in a Black Vulture (Coragyps atratus) in Virginia, A Specific Polymerase Chain Reaction Based on the gyrB Gene Sequence and Subsequent Restriction Fragment Length Polymorphism Analysis of Pasteurella pneumotropica Isolates from Laboratory Mice, Molecular phylogeny of the pinworms of mice, rats and rabbits, and its use to develop molecular beacon assays for the detection of pinworms in mice, A fully integrated microfluidic genetic analysis system with sample-in-answer-out capability, Ribosomal RNA sequences of Clostridium piliforme isolated from rodent and rabbit: Re-examining the phylogeny of the Tyzzer's disease agent and development of a diagnostic polymerase chain reaction assay, A novel mycoplasma detected in association with upper respiratory disease syndrome in free-ranging eastern box turtles (Terrapene carolina carolina) in Virginia, Resolution of ulcerative dermatitis of mice by treatment with topical 0.2% cyclosporine, Phylogenetic Analysis of Avian Poxviruses Among Free-Ranging Birds of Virginia, Phylogenetic classification of the frog pathogen Amphibiothecum (Dermosporidium) Penneri based on small ribosomal subunit sequencing, Successful rederivation of contaminated immunocompetent mice using neonatal transfer with iodine immersion, Avipoxvirus isolate WCV1599-03 4b core protein gene, partial cds, Avipoxvirus isolate WCV78-03 4b core protein gene, partial cds, Avipoxvirus isolate WCV45-03 4b core protein gene, partial cds, Avipoxvirus isolate WCV51-04 4b core protein gene, partial cds, Avipoxvirus isolate WCV22-03 4b core protein gene, partial cds, Avipoxvirus isolate WCV1419-03 4b core protein gene, partial cds, Avipoxvirus isolate WCV34-03 4b core protein gene, partial cds, Avipoxvirus isolate WCV36-03 4b core protein gene, partial cds, Avipoxvirus isolate WCV77-03 4b core protein gene, partial cds, Avipoxvirus isolate WCV33-03 4b core protein gene, partial cds, Avipoxvirus isolate WCV44-03 4b core protein gene, partial cds, Avipoxvirus isolate WCV52-04 4b core protein gene, partial cds, Chytridiomykosis in Amphibians (Dyscophus antongilii) in Switzerland, Amphibiothecum penneri 18S small subunit ribosomal RNA gene, partial sequence, Outbreak of Otitis Media Caused by Burkholderia gladioli Infection in Immunocompromised Mice, Components of gene therapy experimentation that contribute to relative risk, Microchip-Based Purification of DNA from Biological Samples, Comparison of an espB gene fecal polymerase chain reaction assay with bacteriologic isolation for detection of Citrobacter rodentium infection in mice, Diagnostic Molecular Microbiology in Laboratory Animal Health Monitoring and Surveillance Programs, Retrospective Study of Chlamydia trachomatis Using the Polymerase Chain Reaction on Archival Papanicolaou-Stained Cytologic Smears, Evaluation of fentanyl transdermal patches in rabbits: Blood concentrations and physiologic response, Comparison of the deduced amino acid sequence of guinea pig adenovirus hexon protein with that of other mastadenoviruses, Enhanced Airway Th2 Response After Allergen Challenge in Mice Deficient in CC Chemokine Receptor-2 (CCR2), Severe inflammatory defect and reduced viability in CD18 and E-selectin double-mutant mice, Latent Pneumocystis carinii Infection in Commercial Rat Colonies: Comparison of Inductive Immunosuppressants plus Histopathology, PCR, and Serology as Detection Methods, Multifocal necrotizing enteritis with hepatic and splenic infarction associated with Clostridium perfringens type A in a guinea pig raised in a conventional environment, Detection of Pneumocystis carinii in rats by polymerase chain reaction: comparison of lung tissue and bronchoalveolar lavage specimens, Diagnostic molecular microbiology: Detection of pathogenic microorganisms in laboratory animals. Sanford Feldman Professor and Director, Center for Comparative Medicine at University of Virginia Charlottesville, Virginia Area 259 connections Shared Equipment and Personnel Contacts for Training and Information. Flow Cytometry Facility: Shared instrumentation facilities and other resources are available to investigators and trainees interested in research. Creation of a temporary proximal diverting ileostomy is used in high-risk anastomoses, however, additional surgical risk is accumulated with its creation and reversal. Molecular Imaging Core: This facility facilitates and promotes research that utilizes NMR (nuclear magnetic resonance) spectroscopy to examine biologically important molecules, providing information on molecular structure and dynamics at atomic-level resolution. Transgenic rabbits overexpressing human LCAT had 15-fold greater plasma LCAT activity that nontransgenic control rabbits. This center’s mission is to advance education, research, and service concerning moral values in health care. Roux-en-Y gastric bypass (RYGB) consistently produces the most sustainable weight loss among common interventions for morbid obesity. The risk of collateral exposure of laboratory animal care personnel to gene therapy vectors is dependent on a number of factors. The Bioinformatics Core provides expert and timely bioinformatics consulting and data analysis solutions, including management and analysis of large-scale biological datasets produced by high-throughput genomics experiments. UVA Medical Center Executive Vice President for Health Affairs Chief Innovation Officer Chief Medical Officer, UVA Regional Network Corporate Development Officer ... Center for Comparative Medicine Associate Vice President for Research Associate Vice President for Research Development Interim Senior Director, Office of Sponsored Programs The new space will incorporate “open lab” design and will accommodate 8 research faculty members and their postdoctoral fellows, students, and laboratory support staff. Tom Leonard . Anastomotic leaks at the gastrojejunal (GJ) connection result in severe morbidity. Open House. Join ResearchGate to find the people and research you need to help your work. Methods: Despite the fact that pigs are reputed to have excellent olfactory abilities, few studies have examined regions of the pig Ad.RSV beta gal transferred beta-galactosid... Extracellular microelectrode recording of cortical unit activity, with subsequent histological examination, was used to determine the extent, organization, and cytoarchitecture of the zone of muscle afferent projections (kinesthetic cortex) anterior to the primary somatic sensory cortex in anesthetized raccoons. William Petri, Professor, Medicine – Infectious Disease & International Health (UVA School of Medicine), Jason Papin, Professor, Biomedical Engineering (UVA Engineering/UVA School of Medicine) Nephrology Clinical Research Center (NCRC) provides clinical space, equipment, standard protocols, on-site biorepository, and professional staff to conduct a host of patient-oriented studies, clinical trials, epidemiologic studies and outcomes research. Culture of ear exudate specimens from affected mice yielded bacter... Gene therapy is the purposeful delivery of genetic material to somatic cells for the purpose of treating disease or biomedical investigation. The School of Medicine. The core produces and preserves genetically engineered mouse strains for animal model research. The program is devoted to helping those in the public sector who are charged with making decisions to respond to the challenges facing health care systems. Either viral or non-viral vector methods can be used. Center for Biomedical Ethics & Humanities This facility provides access to electron and light microscopes, training in microscope use and sample preparation, a full range of TEM and SEM preparatory services, and consultation regarding microscopy applications in biomedical investigations. This core facility is a central source of tissue culture media, reagents, sterile hood space, cell banking, cell culture consultation, and specialized tissue culture cell services. Join for free and gain visibility by uploading your research. MolMart supplies molecular biology reagents to UVA researchers. Services include preparation of paraffin embedded and frozen tissue sections for routine histology, special stains and immunohistological studies. Tulane University. The UVA Cancer Center is an NCI designated cancer center whose research programs focus on understanding how cancer arises, grows, and spreads and how this knowledge can be used to develop ways to detect, diagnose, treat, and prevent cancer. Top Panel: Renovation of Pinn Hall, 4th floor. model expressing cholesteryl ester transfer protein was evaluated by generating rabbits expressing huma... To evaluate the potential for adenovirus-mediated central nervous system (CNS) gene transfer, the replication deficient recombinant adenovirus vectors Ad.RSV beta gal (coding for beta-galactosidase) and Ad-alpha 1AT (coding for human alpha 1-antitrypsin) were administered to the lateral ventricle of rats. Tissue Culture Facility CD18(-/-)CD62E(-/-), but not CD18(-/-)CD62P(-/-), mice generated by crossbreedi... Histopathologic evaluation combined with a period of immunosuppression has been the standard procedure for detection of Pneumocystis carinii in commercial rat colonies. Pre-release Bd detection can be confounded by imperfect animal sampling and the absence of animals. Beirne B. Carter Center for Immunology Research Ten pigs had an intrathoracic esophageal anastomosis with a 1-cm defect. It has been implicated in marked declines of free-ranging anuran populations. We have completely redesigned approximately 9,000 sq ft of bench laboratory space. Biomolecular Magnetic Resonance Facility (BMRF) W.M. Variation in induction regimens and in the sensitivity of detection methods may result in underreporting of the presence of P. carinii in breeding colonies or delay its detection. The facility provides services to the UVA research community including cell culture and storage services, transfections, baculovirus transfections, viral titering, mycoplasma testing, and training in tissue culture techniques. From this, the amino acid sequence of the cloned portion was deduced and compared with a set of mastadenovirus hexons. Center for Comparative Medicine This center’s mission is to support biomedical research and teaching that utilizes laboratory animals. The open design will facilitate collaboration and expansion of projects. Many soldiers returning from the current conflicts in Iraq and Afghanistan have had at least one exposure to an explosive event and a significant number have symptoms consistent with traumatic brain injury. We immersed neonatal mice in a dilute iodi... Name: Axipox 4b core protein partial CDS isolate WCV36-03. Areas of Research Interest Patterns of growth and causes of growth differences among children with cerebral palsy Impact of growth, nutritional status, and physical development on functional abilities and health-related quality of life among children with cerebral palsy Secondary conditions (e.g. This center is a state-of-the-art optical imaging facility that provides continuous development and implementation of novel optical imaging methods that interface expertise in biology, optics and electronic engineering. Charlottesville, VA 22908 434-924-5118. fax: 434-982-0874 However, there is little information on the intensity and duration of blast necessary to cause brain injury. Anastomotic leak after rectal resection carries substantial morbidity and mortality. David Brenin, MD, FACS is chief of breast surgery, co-director of both the UVA Breast Care Program and the High-Risk Breast and Ovarian Cancer Clinic and is an associate professor of surgery at UVA’s School of Medicine. Radiochemistry Core provides access to new and existing molecular imaging agents that can be detected by Positron Emission Tomography and synthesizes targeted radioimaging agents that give greater specificity than the widely used fluoro-D-glucose (FDG). It includes surgical suites, shared equipment, tissue culture rooms, microscopy room, etc. In 1975, he became the founding Chair of the Department of Comparative Medicine at the University of Washington, a role he retained until becoming an emeritus professor in 1995. Endoluminal vacuum therapy has been shown to seal anastomotic defects in the prophylactic setti... Background: and piriform cortex of adult pigs using several approaches. This chapter discusses occupational health risks to humans associated with research that use laboratory or feral rats. Series Schedule. Jerry was a diplomate of the American College of Laboratory Animal Medicine (ACLAM), served on their board of directors and as president in 1968. The DNA isolated from a histologic section of infected guinea pig lung was subjected to high-fidelity amplificati... To evaluate the role of CCR2 in allergic asthma, mutant mice deficient in CCR2 (CCR2(-/-)) and intact mice were sensitized with i.p. This facility provides high quality histology services and instruction to all UVA investigators. The CIID is a joint research center sponsored by the Schools of Medicine and Veterinary Medicine. UVA Resources Centers, institutes, and programs across UVA Research core facilities at the SOM (see also the Research Cores Handbook) W.M. Additional emphasis is on developing and supporting team science. PO Box 800793. Charlottesville, VA 22908 434-924-5118. fax: 434-982-0874 UVA Today Creative Director Chancellor, The University of Virginia’s College at Wise Provost and Vice Chancellor for Academic Affairs Vice Chancellor ... Center for Comparative Medicine Associate Vice President for Research Development Executive Director, Office of … Biostatistics Blood samples were collect... We sought to isolate, clone, and determine the nucleic acid sequence of the guinea pig adenovirus (GPAdV) hexon gene. This degree of overexpression was associated with a 6.7-fold increase in the plasma HDL cholesterol... Lecithin:cholesterol acyltransferase (LCAT) is a key plasma enzyme in cholesterol and high density lipoprotein (HDL) metabolism. of Biophysics, 1980. Center for Cell Signaling Dr. Sontheimer is an internationally recognized leader in in neuroscience, particularly in glial biology research and the role of […] The Teaching Portfolio is a companion to the more traditional […] One of the most studied animal models of spontaneous Crohn's disease is the senescence-accelerated mouse (SAMP1/Yit strain) model. Center for Medical Education Research and Scholarly Innovation (MERSI), Center for Behavioral Health and Technology, Center for Biomedical Ethics and Humanities, Center for Immunity, Inflammation and Regenerative Medicine, Child Health Research Center (Pediatrics), Institute of Law, Psychiatry and Public Policy, Myles H. Thaler Center for AIDS & Human Retrovirus Research, Translational Health Research Institute of Virginia, Microbiology, Immunology, and Cancer Biology (MIC), Molecular Physiology & Biological Physics, UVA Child Development and Rehabilitation Center, HOSPITAL DRIVE The literature and humanities journal of UVA School of Medicine, Division of Nephrology; Center for Immunity, Inflammation & Regenerative Medicine, Nephrology Clinical Research Center (NCRC), Beirne B. Carter Center for Immunology Research, Biomolecular Magnetic Resonance Facility (BMRF), Biorepository and Tissue Research Facility, Center for Biomedical Ethics & Humanities, Genetically Engineered Murine Model Core (GEMM). OVA with alum on days 0 and 7, and challenged by inhalation with nebulization of either OVA or saline. A state-of-the-art facility dedicated to high-resolution electron cryomicroscopy and electron cryotomography to collect data aimed at high-resolution structural biology projects. The Stem Cell Core provides researchers with high quality inducible pluripotent stem cells (iPSCs) and iPSC derivatives and offers training for those interesting in learning more about iPSC technology. Roux-en-Y gastric bypass (RYGB) consistently produces the most sustainable weight loss among common interventions for morbid obesity. Infection of A2AAR(-/-) mice with Helicobacter hepaticus increased colonic inflammation... Background: --Michigan State University. There is an ongoing need to eradicate intercurrent disease from research mouse colonies. Purpose This PCORI funding announcement invites applications for high-quality comparative effectiveness research (CER) projects that will examine a critical patient-centered research question that is also relevant to decision makers and other stakeholders. Email . Available 24/7, you can get to know our programmes any time of day. Ann Arbor, Mich. : Xerox University Microfilms, 1981. Name . The etiological agent of chytridiomycosis is Batrachochytrium dendrobatidis of the phylum Chytridiomycota. All faculty of the School of Medicine are encouraged to compile a Teaching Portfolio to document activities and accomplishments related to education in the health sciences. The amplicons encompassed a large portion of the mite's ribosomal gene complex spanning 3128 nucleotides containing the entire 18S rRNA, internal transcribed spacer (ITS) 1,5.8S rRNA, ITS2, and a portion of the 5'-end of... SAMP1/YitFcs mice serve as a model of Crohn's disease, and we have used them to assess gastritis. Although blast injury risk functions have been determined and validated for pulmonary injury, there is little information on the blast levels n... On 10 October 2007, a Black Vulture (Coragyps atratus) was presented to the Wildlife Center of Virginia, Waynesboro, Virginia, USA, because of an inability to fly. The Institutional Animal Care and Use Committee is mandated by federal law to oversee the University's animal care and use program, facilities, and procedures and to ensure the appropriate care, use and humane treatment of animals being used for research, testing, and education. community engagement and innovation while promoting shared resources and best practices. Architecture ; Dick Smith ds6cs@virginia.edu Arts & Sciences . Society for Comparative Literature and the Arts; Build Your Resume. 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